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Administering adjuvanted Sm14 to ungulates resulted in high cross-species protection against Fasciola hepatica parasites and liver damage due to T-lymphocyte infiltration, with strong IgM and IgG responses (88–90) suggesting Sm14 as a vaccine candidate with cross-species potential (91, 92)

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Moreover, S1P is part of TGF-β1-induced fibrosis in an in vitro EMT model of uterine adenocarcinoma cells